Eagles WR DeVonta Smith (hamstring) did not practice on Wednesday. He was listed as "DNP" for the first practice of last week, as well, before putting in two limited practices and then playing 89% of the offensive snaps vs. Washington. We're expecting Smith to be fine for Sunday night's game vs. the Rams but will keep you posted on his status.
49ers TE George Kittle (hamstring) was limited in Wednesday's practice. He said afterward that he fully expects to play against the Packers this weekend. Kittle can be penciled back into Week 12 fantasy lineups. We'll let you know if something changes with his status.
49ers QB Brock Purdy (shoulder) was limited in Wednesday's practice. HC Kyle Shanahan hasn't sounded particularly concerned about Purdy's availability for this weekend's game vs. the Seahawks, and the fact that Purdy did anything on Wednesday is encouraging. We'll update his status again tomorrow.
Raiders RBs Alexander Mattison (ankle) and Zamir White (quad) did not practice on Wednesday. Both guys were knocked out of the Week 11 loss to the Dolphins and are seemingly in danger of missing Sunday's game vs. the Broncos. Their absences would leave the backfield to Ameer Abdullah and Dylan Laube. The former hasn't tallied double-digit carries in a game since 2017; the latter is a sixth-round rookie who fumbled on his only touch of the season. We'll keep you updated on Mattison and White, but this is a backfield to avoid in Week 12 fantasy lineups.
Cowboys TE Jake Ferguson (concussion) did not practice on Wednesday. With just six days to clear protocol, he's a long shot to play vs. the Commanders this weekend. That'll leave TE duties to Luke Schoonmaker and Brevyn Spann-Ford. Schoonmaker racked up six catches on 10 targets in the Week 11 loss to Houston but ran just four more routes than Spann-Ford. We'd try to avoid the situation in Week 12 fantasy lineups.
Giants WR Darius Slayton (concussion) was a full participant in Wednesday's practice. Barring a setback, he'll play against the Bucs this weekend. Tampa Bay ranks 29th in adjusted fantasy points allowed to WRs, but Slayton would be a desperation fantasy play with QB Tommy DeVito.
Lions TE Sam LaPorta (shoulder) was a full participant in Wednesday's practice. HC Dan Campbell confirmed that LaPorta is "trending the right way" for this weekend's game vs. the Colts. Although he's been one of the most disappointing players in fantasy football this season, LaPorta has finished as a top-8 TE in two of his last three outings. And Sunday brings a matchup against the league's 30th-ranked TE defense.
Titans RB Tyjae Spears (concussion) did not practice on Wednesday. He's a long shot to be cleared in time for Sunday's game vs. the Texans. His absence would leave RB Tony Pollard in a workhorse role -- albeit in a tough matchup against the league's No. 4 RB defense.
Bears RB D'Andre Swift (groin) did not practice on Wednesday. HC Matt Eberflus said Swift is dealing with "just a little bit of a groin strain" and said he's "hopeful" Swift will be able to play vs. the Vikings this weekend. It sounds like there's at least some chance, though, that Swift won't be able to go. That'd presumably leave Roschon Johnson as Chicago's lead back. He should be rostered in all fantasy leagues of 10+ teams.
Panthers WR Adam Thielen (hamstring) was limited in Wednesday's practice. HC Dave Canales said Monday that he expects Thielen to play this weekend, but he'd be a shaky fantasy start against the Chiefs' 10th-ranked WR defense.
Chiefs HC Andy Reid wouldn't say Wednesday whether RB Isiah Pacheco (leg) will play against the Panthers this weekend, calling it a "day by day type thing." Pacheco returned to practice last week, getting in three limited sessions. NFL Network's Ian Rapoport said Sunday morning that Pacheco will be healthy enough to play Week 12 but that the team could opt to hold him out as a precaution. We'll keep you updated on the situation. Kareem Hunt would be a top-12 RB play if Pacheco remains out this weekend.
Packers RB MarShawn Lloyd will be placed on the Non-Football Injury List after last week's appendicitis, HC Matt LaFleur said Wednesday. That knocks the tough-luck rookie out for at least the next four games. We won't see him until Week 16 at the earliest. Lloyd can be dropped from all redraft rosters.
Buccaneers WR Mike Evans (hamstring) is "planning to play" vs. the Giants this weekend, according to insider Jordan Schultz. Evans has been out since Week 7 but will be returning to a Chris Godwin-less WR corps. That gives Evans a chance to be big volume the rest of the way. He checks in 10th in our current Week 12 WR Rankings. We'll track his practice participation throughout the week and looks for any reports on Tampa's plans for his snaps in his first game back.
Cowboys WR Brandin Cooks (knee) has been designated to return from IR. He'll practice this week and is eligible to play against the Commanders on Sunday. Cooks was sitting 71st among WRs in PPR points with QB Dak Prescott through Week 4. It's tough to expect better with QB Cooper Rush (or QB Trey Lance). Cooks can be left on fantasy waiver wires.
Raiders QB Aidan O’Connell is expected to return "in a week or two," per beat writer Vic Tafur. The 26-year-old remains on IR with a broken thumb. Given Gardner Minshew’s struggles, it’s quite possible the team goes back to O’Connell when healthy. He’s worth stashing in deep superflex formats.
Cowboys WR CeeDee Lamb was targeted 12 times against the Texans. He caught eight passes for 93 yards, but couldn’t find the end zone with QB Cooper Rush at the helm.
Texans WR Nico Collins played his first game in over six weeks, catching four passes 54 yards on seven targets. He did have a TD called back due to a penalty. Collins has retained his athleticism, but struggled for most of the night against Trevon Diggs.
Texans RB Joe Mixon had his way with the Dallas Cowboys on Monday Night Football. He ran 20 times for 109 yards and three TDs while also adding two catches for 44 yards. He has been a Fantasy MVP since returning from his ankle injury.
Cowboys TE Jake Ferguson left Monday night's game against the Texans in the first quarter and has entered the concussion protocol. It's the second diagnosed concussion of Ferguson's NFL career. The last came in December of 2022. We'll see how he fares with a shorter turnaround to next Sunday's game at Washington. You should start the week planning to not have Ferguson in Week 12.
49ers TE George Kittle (hamstring) is expected to practice on Wednesday, HC Kyle Shanahan said. That makes Kittle likely to play vs. the Packers this weekend, barring a setback. We'll keep you updated on his status.
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