49ers HC Kyle Shanahan said after Sunday night's loss to the Bills that RB Christian McCaffrey has a PCL injury that could be season-ending. McCaffrey will likely undergo additional testing on Monday to get a better look at the damage. We should get another update on his status over the next 24 hours. McCaffrey's absence would leave Jordan Mason as San Francisco's lead back once again. He out-carried RB Isaac Guerendo 13 to four in Buffalo. Mason, who's rostered in only 37% of Sleeper leagues, is the top target on waiver wires this week.

49ers RB Christian McCaffrey is on track to return on November 10th against the Tampa Bay Buccaneers in Week 10. There have been no setbacks with his Achilles tendinitis and the 49ers are planning for him to return in about three weeks.

49ers HC Kyle Shanahan labeled RB Jordan Mason "day to day" with the sprained AC joint he suffered in his left shoulder in Thursday night's win over the Seahawks. Mason has another nine days to heal up for a Week 7 showdown with the Chiefs. It sounds like he has a good chance to be ready for that one. We'll track his status throughout next week.