Titans RB Tyjae Spears (hamstring) practiced all week and is off the final injury report. He’ll play vs. the Chargers on Sunday for the first time since Week 6. Spears averaged 6.8 carries and 3.0 targets per game over the first four weeks of the season, so he'd be a desperation Week 10 fantasy start. But his return is a slight ding to RB Tony Pollard's outlook.
Jaguars RB D’Ernest Johnson (hamstring) is questionable for this weekend’s game vs. the Vikings. He was added to the injury report on Thursday and limited again on Friday. Johnson stayed involved last week, despite RB Travis Etienne’s return, handling two carries and one target on a 24% snap rate. Johnson’s absence this weekend would be a slight boost to Etienne and RB Tank Bigsby.
Jaguars WR Gabe Davis (shoulder) was limited in practice all week and is listed as questionable for Sunday’s game vs. the Vikings. We’re expecting him to play, but Davis is far from a fantasy option with QB Mac Jones under center.
Jaguars WR Brian Thomas (chest) is listed as questionable for Sunday's game vs. the Vikings. He played through this injury last week, so we're fully expecting him to be out there against Minnesota. Thomas posted a season-worst 2-22-0 line last week but played 91% of the offensive snaps. QB Mac Jones is a bigger concern for Thomas' Week 10 fantasy outlook than the chest injury.
Jaguars QB Trevor Lawrence (left shoulder) is listed as questionable for Sunday’s game vs. the Vikings after a limited week of practice. HC Doug Pederson admitted on Friday, though, that Lawrence is unlikely to play. That’ll leave QB Mac Jones at the helm for his first start in almost a year. Jones’ career passing numbers are similar to Lawrence’s, but we’re still considering him a downgrade for Jacksonville’s offense.
Cowboys QB Dak Prescott (hamstring) is out for Sunday’s game vs. the Eagles. The team is still deciding whether Prescott will go on IR, which would cost him at least four games. QB Cooper Rush will make his first start this weekend since 2022. He owns a career 60.0% completion rate and 6.5 yards per attempt. While not the worst backup in the world, Rush is obviously a significant downgrade from Prescott for Dallas’ offense.
The Commanders have ruled RB Brian Robinson Jr. out for Sunday's game against the Steelers with the hamstring injury that also cost him Week 9. Robinson managed limited practices Wednesday and Thursday after putting in limited workouts all last week and carrying a "questionable" tag into the game. But he missed Friday's practice this time around and got ruled out early.
Texans RB Dameon Pierce (groin) is out for Sunday night’s game vs. the Lions. He’ll be replaced again by RB J.J. Taylor, who is not a fantasy option. RB Joe Mixon should be in for another big workload.
Commanders K Austin Seibert is questionable with a right hip injury for their Week 10 game against the Steelers. Seibert has been the highest scoring fantasy kicker this year, but his status is up in the air.
Cowboys WR CeeDee Lamb (shoulder) is not listed on the final Week 10 injury report. He practiced all week, including a full workout on Friday, and will play against the Eagles on Sunday. There’s some re-injury risk with the shoulder. And Lamb will be catching passes from backup QB Cooper Rush. But he remains a strong target bet and would be tough to leave out of fantasy lineups. See where Lamb sits in the Week 10 WR Rankings.
Texans WR Tank Dell was listed as Questionable on the final injury report after a limited practice on Friday. Dell's Week 10 status is now in jeopardy after sustaining the injury at practice.
Texans WR Nico Collins (hamstring) is listed as questionable for Sunday night's game vs. the Lions. He was just designated to return on Friday, putting in his first official practice since going down in Week 5. It remains uncertain if he'll play against Detroit. We should get more updates on Collins between now and Sunday morning, but the late kickoff could put Collins owners in a tough spot. He'd be tough to leave out of fantasy lineups if he ends up playing.
Eagles TE Dallas Goedert (hamstring) put in a full week of practice and will play vs. the Cowboys on Sunday. It looks like he’s ready for a full slate of snaps in his first action since Week 6. But with WRs A.J. Brown and DeVonta Smith available – and the Eagles unlikely to pass much vs. the Cooper Rush-led Cowboys – Goedert is a fringe TE1.
Eagles WR DeVonta Smith (hamstring) is not listed on the final injury report for Sunday's game vs. the Cowboys. He went from no practice on Wednesday to limited participation on Thursday to full-go Friday. Smith is fine to use as you normally would in fantasy lineups.
Eagles WR A.J. Brown (knee) is not listed on the final Week 10 injury report. He put in full practices on Thursday and Friday, so it doesn’t look like the knee will be a significant issue in Sunday’s game vs. the Cowboys. Brown remains a must-start in that one.
Saints RB Jamaal Williams (groin) is listed as questionable for this weekend’s game vs. the Falcons. Interim HC Darren Rizzi said Friday that Williams aggravated his groin injury in practice this week and is unlikely to play. Jordan Mims will serve as No. 2 RB on paper again, but TE Taysom Hill is the second-best bet for carries behind workhorse Alvin Kamara.
Saints WR Chris Olave (concussion) is out for Sunday’s game vs. the Falcons. Interim HC Darren Rizzi said Friday that the team is still considering placing Olave on IR after his fifth documented concussion. That decision would likely come on Saturday. Stay tuned.
Bills WR Amari Cooper (wrist) is listed as questionable for Sunday's game vs. the Colts after a limited week of practice. It’s the same boat he was in last week before missing the Dolphins game. We’ll look for further updates on Cooper’s status and get Buffalo’s inactives around 11:30 am ET on Sunday.
Steelers RB Cordarrelle Patterson (ankle) put in a full week of practice and is off the final injury report. He’ll play vs. the Commanders on Sunday for the first time since Week 4. Patterson averaged 4.0 carries and 1.8 targets over the first four games of the season. He’s not a fantasy option but could put a slight dent in RBs Najee Harris and Jaylen Warren’s volume.
Chiefs WR JuJu Smith-Schuster (hamstring) is out for Sunday’s game vs. the Broncos. He remained sidelined in practice all week and has no timetable for return. QB Patrick Mahomes will continue to lean on TE Travis Kelce and WR DeAndre Hopkins this week. We’ll see if WR Xavier Worthy can bounce back from a rough outing vs. the Bucs on Monday night.
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