Colts QB Anthony Richardson (oblique) was upgraded to full participation in Thursday's practice. It's his first full practice since going down in Week 4 and has him on track to return for Sunday's game vs. the Titans. Richardson will be working with an undermanned pass-catching corps, though, with WR Michael Pittman definitely out and WR Josh Downs potentially out.
Colts WR Josh Downs (toe) remained sidelined for Thursday's practice. He's seemingly in legitimate danger of missing this weekend's game vs. the Titans. That'd leave Indianapolis without its top two WRs in Downs and Michael Pittman. Alec Pierce, Adonai Mitchell, and Ashton Dulin would be left as the team's top three WRs. We'll update Downs' status again tomorrow.
Bills WR Khalil Shakir (ankle) did not practice on Thursday. He still has a few days to get ready for Monday night's game vs. the Jets, but consider him no better than 50/50 for that one. QB Josh Allen missed Shakir last week, completing just nine of 30 passes in the loss to the Texans. We'll see if Shakir gets back on the field tomorrow.
Bills RB James Cook (toe) did not practice on Thursday. We don't have any other details on the toe injury. Cook has an extra day to get ready for Monday night's game vs. the Jets, but consider him iffy for that one as of now. His absence would likely mean a committee backfield with RBs Ray Davis and Ty Johnson. Davis would be the better fantasy bet but only a RB3 or Flex play.
Giants WR Malik Nabers (concussion) remained sidelined for Thursday's practice. With multiple stages of the protocol to pass through still, he's unlikely to be cleared in time for Sunday night's game vs. the Bengals. We'll update Nabers' status again tomorrow but are removing him from the Week 6 Rankings for now. Nabers' absence boosts the target projections for WRs Wan'Dale Robinson and Darius Slayton.
Packers HC Matt LaFleur said Thursday that TE Luke Musgrave (ankle) will "more than likely" go on IR. That'd knock him out for the next four games, which runs into Green Bay's Week 10 bye. Musgrave can be dropped in all redraft leagues. His absence locks in TE Tucker Kraft as a full-time player -- and a fantasy TE1.
Todd Downing will replace Nathaniel Hackett as the Jets' play-caller, interim HC Jeff Ulbrich announced on Thursday. While defensive-minded HC Robert Saleh was canned earlier this week, the offense has been the real problem in New York. The Jets rank 23rd in points, 27th in total yards, and 27th in yards per play. That's largely on Hackett, who has deployed a stale offense. We're just not sure it'll get much better with Downing. He's spent three seasons as an NFL OC, one with the Raiders and two with the Titans. Those offenses ranked 17th, 17th, and 30th in total yards. QB Aaron Rodgers is on board with the move, according to insider Connor Hughes. We'll get our first look at Downing's offense in Monday night's Jets vs. Bills game.
The Bears have already ruled S Jaquan Brisker out for Sunday's game against the Jaguars in London. He didn't travel with the team after suffering a concussion in the Week 5 win over Carolina. Brisker passed a concussion check during that game and returned but then reported symptoms Monday.
The Seahawks have ruled CB Riq Woolen (ankle) and DT Byron Murphy (hamstring) out for Thursday night's game against the 49ers. Edge Uchenna Nwosu (thigh) is also out and expected to land on IR ahead of the game. Additionally, Seattle lists Edge Derick Hall (foot), Edge Boye Mafe (knee), and S Julian Love (hamstring) as questionable vs. San Francisco. Love played through the same issue in Week 5, missing just one of 71 snaps. But HC Mike Macdonald calls him a game-time decision on the short week. Macdonald said Wednesday he's "confident" Hall and Mafe will play. Each practiced in full Wednesday.
Giants RB Devin Singletary (groin) got in a limited practice on Wednesday. HC Brian Daboll said afterward that Singletary is "trending in the right direction." We're expecting him back for Sunday night's game vs. the Bengals, although it's possible that Singletary cedes more work to RB Tyrone Tracy.
Giants WR Malik Nabers (concussion) remained sidelined for Wednesday's practice. It's surprising and concerning that he's still out 13 days after his concussion. HC Brian Daboll said that Nabers is "doing better" and "day-to-day." But his availability for Sunday night's game vs. the Bengals is in jeopardy. Nabers likely needs to practice tomorrow to have a chance to be cleared for that one.
Bengals RB Zack Moss (foot) did not practice on Wednesday. He appeared to get banged up late in last week's loss to the Ravens, and his status for Sunday night's game vs. the Giants is now uncertain. Moss' absence would turn RB Chase Brown into a must-start. We'll see if Moss gets back on the field tomorrow.
Panthers WR Xavier Legette (shoulder) was a full-go in Wednesday's practice. He was knocked out early in last weekend's game but is on track to play vs. the Falcons this weekend. Legette should step back in as Carolina's No. 2 WR and is a WR4 consideration for fantasy squads.
Raiders RB Zamir White (groin) did not practice on Wednesday. With White out last week, RB Alexander Mattison played 57% of Vegas' offensive snaps and handled 15 carries with three targets. Expect a similar workload this weekend if White remains out, but a matchup against the Steelers' 11th-ranked RB defense would leave Mattison as an unexciting RB3.
Broncos RB Audric Estime (ankle) has been activated from IR and put in a full practice on Wednesday. It looks like he'll be available for this weekend's game vs. the Chargers. Estime lost a fumble and then hurt his ankle in the opener, so we wouldn't expect him to have a significant role in the short term. We'll see if the rookie can work his way into Denver's backfield rotation.
Chargers RB Gus Edwards (ankle) did not practice on Wednesday. It could be an early-week rest day for the veteran, but the Chargers are coming off their bye week. We'll see if Edwards gets back on the field tomorrow. If he misses Sunday's game vs. the Broncos, we could see rookie RB Kimani Vidal make his regular-season debut.
Titans QB Will Levis (shoulder) put in a full practice on Wednesday. That has him on track to start this weekend's game vs. the Colts. The biggest fantasy impact there? The Colts DST is a nice Week 6 option. Levis has six INTs and three fumbles in a little more than three games this season.
Colts RB Jonathan Taylor (ankle) remained sidelined for Wednesday's practice. "He’s working through it, he’s looking good," HC Shane Steichen said of JT. "We’ll see how the week goes for him, hopeful that he’ll be out there." Fantasy owners should not be counting on Taylor in Week 6 fantasy lineups. RB Trey Sermon (collarbone) also missed Wednesday's practice. No word on his status for Sunday's game vs. the Titans. If Taylor and Sermon are out, RB Tyler Goodson would be left as Indianapolis' starter.
Colts QB Anthony Richardson (oblique) remained limited in Wednesday's practice. He was limited all last week before missing the Jaguars game. Richardson's status for this weekend's game vs. the Titans remains uncertain. We'll track his progress over the next few days.
Eagles WRs A.J. Brown (hamstring) and DeVonta Smith (hamstring) were full participants in Wednesday's practice. They're both on track to return and play their usual roles vs. the Browns this weekend. Get them back into fantasy lineups.
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