49ers WR Deebo Samuel (rib, wrist) is out for Sunday's game vs. the Cardinals. Although he's had a disappointing season, Samuel has averaged 5.0 targets and 3.0 carries over the last five games. So his absence leaves extra opportunity for WRs Jauan Jennings and Ricky Pearsall and RB Isaac Guerendo.

49ers WR Deebo Samuel broke out of a slump with 7 catches, 96 yards, and 1 score in Week 16. That snapped a seven-game scoreless streak.

49ers WR Jauan Jennings caught seven of his eight targets for 90 yards and two TDs. Teammate Deebo Samuel had a rougher go of it catching only two of his three targets for 22 yards. Samuel also ran the ball five times for only 13 yards.

49ers QB Brock Purdy (shoulder) is active for tonight’s game vs. the Bills. He had a good week by all accounts, progressing to a full practice on Friday. There’s still elevated risk to using Purdy in fantasy lineups with the throwing shoulder issue, though. And the spot is tough against the Bills’ ninth-ranked QB defense in wintery Buffalo. Purdy is not a recommended QB1 play – but his return is good news for San Francisco’s skill-position players. QB Brandon Allen is inactive as the emergency third QB tonight, leaving QB Josh Dobbs as the backup.