Isaac Guerendo Injury History & Analysis

The 49ers are trading RB Jordan Mason to the Vikings, according to multiple reports. Mason is getting a two-year, $7 million deal with Minnesota that carries a max value of $12 million. The Niners are getting back just a 2026 sixth-rounder and a pick swap in this year's draft, according to NFL Network.

ESPN's Adam Schefter reports that the 49ers have tendered RB Jordan Mason at the second-round level. That still leaves Mason open to sign with other teams, but any team that signs Mason would have to send San Francisco a second-round pick.

49ers RB Isaac Guerendo injured his left leg on the first drive of Sunday's game vs. the Cardinals. He was quickly ruled out for the rest of the game with knee and ankle injuries. We'll update Guerendo's status when we know more, but this looks like a serious injury.

49ers WR Deebo Samuel (rib, wrist) is out for Sunday's game vs. the Cardinals. Although he's had a disappointing season, Samuel has averaged 5.0 targets and 3.0 carries over the last five games. So his absence leaves extra opportunity for WRs Jauan Jennings and Ricky Pearsall and RB Isaac Guerendo.

49ers RB Isaac Guerendo (foot, hamstring) is not listed on the final Week 17 injury report. He was a full participant in Saturday's practice and seems ready to take back over as San Francisco's clear lead back in Monday night's game vs. the Lions. Guerendo checks in 17th in the Week 17 RB Rankings.