Texans RB Dameon Pierce (hamstring) is inactive for today's game vs. the Bills. That again leaves the backfield to Cam Akers, Dare Ogunbowale, and J.J. Taylor. Akers figures to lead in touches but ceded carries to Taylor and passing-down snaps to Ogunbowale last week.

Texans RB Dameon Pierce (hamstring) is not expected to play vs. the Bills today, according to ESPN's Adam Schefter. Pierce just returned to a limited practice on Friday after missing the last three games, so it's no surprise that he's not ready yet. With RB Joe Mixon (ankle) also out, Houston will again roll with RBs Cam Akers, Dare Ogunbowale, and J.J. Taylor.

Texans RB Joe Mixon (ankle) is not expected to play vs. the Bills this weekend, according to NFL Network's Ian Rapoport. Mixon was limited in practice last Friday but has missed the first two practices of this week. So it looks like he suffered a setback.